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Examples of ototoxic cytostatic agents Methotrexate : Associated with temporary or permanent SHL in some patients, likely due to its interference with folate metabolism and resultant neurotoxicity

In primary adrenal insufficiency, mineralocorticoid replacement using fludrocortisone, is also given when the patient is stable

apply a small amount to the wrist area and allow it to sit for a few minutes

10.1155/2014/762320 Adv

Six LOX subtypes are expressed in humans [300]: ALOX5, ALOX12, ALOX12B, ALOX15, ALOX15B, and ALOXE3

This multi-use capability is particularly valuable in in vivo rodent research requiring daily or twice-daily peptide administration across multi-week study durations, in dose-response studies requiring multiple concentration preparation from a single reconstituted stock, and in comparative pharmacology protocols requiring repeated access to multiple reconstituted compound vials simultaneously